Study finds long-acting shot helps women avoid HIV infection
A shot every two months of the experimental medicine cabotegravir is more effective than daily Truvada pills at preventing women from acquiring HIV from an infected sex partner, a study finds. The regimen worked so well that researchers are stopping the study early.
The news is a boon for AIDS prevention efforts, experts say. That’s especially true in Africa, where the study took place and where women have few discreet ways of protecting themselves from infection.
Results so far suggest that the drug, cabotegravir, was 89% more effective at preventing HIV infection than Truvada pills, although both reduce that risk.
The results mirror those announced earlier this year from a similar study testing the shots versus the daily pills in gay men.
A spate of large-scale clinical trials has scientists hopeful about a vaccine to prevent HIV.
Cabotegravir is being developed by ViiV Healthcare, which is mostly owned by GlaxoSmithKline, with Pfizer Inc. and Shionogi Limited. The study was sponsored by the U.S. National Institutes of Health, the Bill and Melinda Gates Foundation and ViiV. The drugs were provided by ViiV and Truvada’s maker, Gilead Sciences.
“This is a major, major advance,” said Dr. Anthony Fauci, the top infectious disease doctor at the NIH. “I don’t think we can overemphasize the importance of this study.
It promises HIV prevention help to young women, “those who need it the most,” he said.
Young women may be twice as likely as men to get HIV in some areas of the world, according to one study leader, Sinead Delany-Moretlwe of the University of the Witwatersrand in Johannesburg, South Africa.
“They need discreet options ... without having to negotiate with their partners” to use measures such as condoms, said Deborah Waterhouse, chief executive of ViiV.
The study involved more than 3,200 participants in seven African countries who were randomly assigned to receive either the shots every two months or daily Truvada pills. Independent monitors advised stopping the study after seeing that only 0.21% of women receiving the shots caught the human immunodeficiency virus virus versus 1.79% of women on the pills.
There were more side effects, mostly nausea, with the daily pills.
Cabotegravir’s makers are seeking approval from regulators to sell it for this purpose, and Truvada already is widely used.
A Brazilian man infected with HIV has shown no sign of it for more than a year since he stopped HIV medicines after an experimental drug therapy.
“The urgent work now” is to make all prevention medicines affordable and more widely available, said Mitchell Warren, who heads AVAC, formerly known as the AIDS Vaccine Advocacy Coalition, a nonprofit focused on prevention efforts that had no role in the study.
Condoms remain widely recommended because they help prevent a host of sexually spread diseases, not just HIV.
“People need choices for HIV prevention,” and this gives a new option, Warren said in a statement.
