Photos: George Clooney: Life in pictures

Clooney has his cousin Miguel Ferrer to thank for giving him his first mini-role in Ferrer’s horse racing film “And They’re Off.” Nearly 10 years later, Clooney landed his breakout TV role as seasoned pediatrician and expert womanizer Dr. Doug Ross on “ER.”  (Patrick Downs / Los Angeles Times)

Clooney then starred in a comedy chronicling two single working parents (Michelle Pfeiffer and Clooney) and their children, who encounter a day full of surprises.  (Gemma La Mana / For The Times)

With Ben Affleck, center, and close freind Grant Heslov, Clooney held the producer’s role in the political thriller “Argo.” With Oscar nods for “Argo” in 2013, it made Clooney the only person in Academy Award history to be nominated across six categories.  (Kirk McKoy / Los Angeles Times)

The Hollywood bachelor tied the knot with Beirut-born human rights lawyer Amal Alamuddin in September. It’s the second marriage for Clooney, who was previously wed to Talia Balsam from 1989 to 1993.  (Luca Bruno / AP)